GSK4112

GSK4112 (SR6452) is a Rev-erbα agonist with an EC50 value of 0.4 μM. GSK4112 can be used as a chemical tool to probe the function of Rev-erbα in transcriptional repression, regulation of circadian biology, and metabolic pathways[1].

Product Specifications

CAS Number

[1216744-19-2]

Product Name Alternative

SR6452

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; REV-ERB

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/GSK4112.html

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

ClC1=CC=C(CN(CC2=CC=C([N+]([O-])=O)S2)CC(OC(C)(C)C)=O)C=C1

Molecular Formula

C18H21ClN2O4S

Molecular Weight

396.89

Precautions

H302, H315, H319, H335

References & Citations

[1]Grant D, et al. GSK4112, a small molecule chemical probe for the cell biology of the nuclear heme receptor Rev-erbα. ACS Chem Biol. 2010 Oct 15;5 (10) :925-932.|[2]Shao R, et al. REV-ERBα Agonist GSK4112 attenuates Fas-induced Acute Hepatic Damage in Mice. Int J Med Sci. 2021 Oct 25;18 (16) :3831-3838.