S-methyl DM1

S-methyl DM1 is a thiomethyl derivative of Maytansine. S-methyl DM1 binds to tubulin with a Kd of 0.93 μM and inhibts microtubule polymerization. S-methyl DM1 potently suppresses microtubule dynamic instability and has anticancer effects[1][2].

Product Specifications

CAS Number

[912569-84-7]

UNSPSC

12352203

Target

ADC Payload; Microtubule/Tubulin

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-methyl-dm1.html

Concentration

10mM

Purity

99.58

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@]1([C@@](CC(N(C2=CC3=CC(OC)=C2Cl)C)=O)([H])OC([C@H](C)N(C)C(CCSC)=O)=O)[C@H]([C@@H]([C@](OC4=O)([H])C[C@]([C@](/C=C/C=C(C)/C3)([H])OC)(N4)O)C)O1

Molecular Formula

C36H50ClN3O10S

Molecular Weight

752.31

References & Citations

[1]Lopus M, et al. Maytansine and cellular metabolites of antibody-maytansinoid conjugates strongly suppress microtubule dynamics by binding to microtubules. Mol Cancer Ther. 2010 Oct;9 (10) :2689-99.|[2]Oroudjev E, et al. Maytansinoid-antibody conjugates induce mitotic arrest by suppressing microtubule dynamic instability. Mol Cancer Ther. 2010 Oct;9 (10) :2700-13.