Sisomicin (sulfate)

Sisomicin sulfate is a broad-spectrum aminoglycoside antibiotic produced by Micromonospora inyoensis. Sisomicin sulfate is highly active against Gram-positive bacteria[1][2][3][4].

Product Specifications

CAS Number

[53179-09-2]

UNSPSC

12352211

Hazard Statement

H360

Target

Antibiotic; Bacterial

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Sisomicin-sulfate.html

Purity

99.15

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@@]3([H])OC[C@@](O)(C)[C@H](NC)[C@H]3O)[C@H]2O)([H])OC(CN)=CC1.[2.5H2SO4]

Molecular Formula

C19H37N5O7.5/2H2SO4

Molecular Weight

692.72

Precautions

H360

References & Citations

[1]P Noone, et al. Sisomicin, netilmicin and dibekacin. A review of their antibacterial activity and therapeutic use. Drugs. 1984 Jun;27 (6) :548-78.|[2]Crowe CC, et al. Sisomicin: evaluation in vitro and comparison with gentamicin and tobramycin. Antimicrob Agents Chemother. 1973 Jan;3 (1) :24-8.|[3]Le Moli S, et al. In vitro and in vivo effect of sisomicin and gentamycin on polymorphonuclear chemotaxis and phagocytosis. Int J Immunopharmacol. 1983;5 (1) :49-54.|[4]Fabre J, et al. Persistence of sisomicin and gentamicin in renal cortex and medulla compared with other organs and serum of rats. Kidney Int. 1976 Dec;10 (6) :444-9.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Natural Products

Clinical Information

Launched

Isoform

Aminoglycoside

Citation 01

ACS Biomater Sci Eng. 2024 Apr 24.|Curr Microbiol. 2021 Dec 14;79 (1) :12.|Research Square Preprint. 2024 Apr 1.|STAR Protoc. 2024 Jun 7;5 (2) :103118.|ACS Infect Dis. 2024 Apr 12;10 (4) :1327-1338.