Multi-kinase inhibitor 3

Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity[1].

Product Specifications

CAS Number

[2648279-76-7]

UNSPSC

12352005

Target

FLT3; PDGFR; VEGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/multi-kinase-inhibitor-3.html

Smiles

CN1N=CC(C2=CC=C(N(C3=CC=C(CC(NC4=CC(C(C)(C)C)=NO4)=O)C=C3)C=N5)C5=C2)=C1

Molecular Formula

C26H26N6O2

Molecular Weight

454.52

References & Citations

[1]Das D, et al. Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models. Bioorg Med Chem Lett. 2024 Sep 19;113:129971.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PDGFRα; PDGFRβ; VEGFR1/Flt-1; VEGFR2/KDR/Flk-1; VEGFR3/Flt-4

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