Multi-kinase inhibitor 3
Product Specifications
UNSPSC Description
Multi-kinase inhibitor 3 (compound 12) is a potent and orally active multikinase inhibitor with IC50 values of 1.59, 1.23, 1.19, 0.59, 0.22, 1.15 nM for FLT1/VEGFR1, KDR/VEGFR2, FLT4/VEGFR3, FLT3, PDGFRα, PDGFRβ, respectively. Multi-kinase inhibitor 3 shows antiproliferative activity. Multi-kinase inhibitor 3 shows anticancer activity[1].
Target Antigen
FLT3; PDGFR; VEGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/multi-kinase-inhibitor-3.html
Smiles
CN1N=CC(C2=CC=C(N(C3=CC=C(CC(NC4=CC(C(C)(C)C)=NO4)=O)C=C3)C=N5)C5=C2)=C1
Molecular Weight
454.52
References & Citations
[1]Das D, et al. Discovery of novel, orally bioavailable phenylacetamide derivatives as multikinase inhibitors and in vivo efficacy study in hepatocellular carcinoma animal models. Bioorg Med Chem Lett. 2024 Sep 19;113:129971.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-168114/Multi-kinase-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-168114/
Clinical Information
No Development Reported
CAS Number
2648279-76-7
Curated Selection
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