GFRAL, Human (His-SUMO)

The GFRAL protein is a brainstem-restricted receptor for GDF15 that regulates food intake, energy expenditure, and body weight in response to metabolic and toxin-induced stress. GFRAL binds to its ligand GDF15, interacts with RET, and activates the MAPK and AKT signaling pathways. GFRAL Protein, Human (His-SUMO) is the recombinant human-derived GFRAL protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of GFRAL Protein, Human (His-SUMO) is 333 a.a., with molecular weight of ~53.8 kDa.

SQTNNCTYLR EQCLRDANGC KHAWRVMEDA CNDSDPGDPC KMRNSSYCNL SIQYLVESNF QFKECLCTDD FYCTVNKLLG KKCINKSDNV KEDKFKWNLT TRSHHGFKGM WSCLEVAEAC VGDVVCNAQL ASYLKACSAN GNPCDLKQCQ AAIRFFYQNI PFNIAQMLAF CDCAQSDIPC QQSKEALHSK TCAVNMVPPP TCLSVIRSCQ NDELCRRHYR TFQSKCWQRV TRKCHEDENC ISTLSKQDLT CSGSDDCKAA YIDILGTVLQ VQCTCRTITQ SEESLCKIFQ HMLHRKSCFN YPTLSNVKGM ALYTRKHANK ITLTGFHSPF NGE