Vitexin B-1

Vitexin B-1 is an inhibitor of Bcl-2 and the agonist of Caspase. Vitexin B-1 has cytotoxic effect and induces apoptosis in MCF-7, ZR-75-1, MDA-MB-231, and COC1 cells with IC50s of 3.2, 2.1, 1.8 and 0.39 μM, respectively[1].

Product Specifications

CAS Number

[357645-16-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bcl-2 Family

Type

Natural Products

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/vitexin-b-1.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](C2=CC(OC)=C(O)C=C2)C3=CC(O)=C(OC)C=C3C=C1C=O

Molecular Formula

C20H20O6

Molecular Weight

356.37

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Zhou Y, et al. Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth. Clin Cancer Res. 2009 Aug 15;15 (16) :5161-9.