M-PEG-OH (MW 20000)

M-PEG-OH (MW 20000) can be used as a macroinitiator to participate in the synthesis of amphiphilic block copolymers. Nanoscale micelles can be prepared by using amphiphilic block copolymers to deliver active drugs. Paclitaxel (HY-B0015), a hydrophobic anticancer agent encapsulated in micelles, has stronger activity in killing cancer cells than free Paclitaxel. And it preferentially accumulates in tumor tissue with only limited distribution in healthy organs.

Product Specifications

CAS Number

[9004-74-4]

Product Name Alternative

MPEG-Hydroxy (MW 20000) ; Polyethylene glycol monomethyl ether (MW 20000)

UNSPSC

12352200

Hazard Statement

H315, H319, H335

Target

PROTAC Linkers

Type

Biochemical Assay Reagents

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/m-peg-oh-mw-20000.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

COCCOCCO.[n]

Molecular Weight

20000 (Average)

Precautions

H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562|[2]Lee AL, et al. The use of cholesterol-containing biodegradable block copolymers to exploit hydrophobic interactions for the delivery of anticancer drugs. Biomaterials. 2012 Feb;33 (6) :1921-8.