Trofinetide
Trofinetide (NNZ-2566), a synthetic analogue of the endogenous N-terminus tripeptide, Glycine-Proline-Glutamate (GPE), has been shown to be neuroprotective in animal models of brain injury.
Product Specifications
CAS Number
853400-76-7
Product Name Alternative
NNZ-2566
UNSPSC
12352209
Target
IGluR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Trofinetide.html
Purity
99.90
Solubility
H2O : ≥ 50 mg/mL|H2O : 110 mg/mL (ultrasonic)
Smiles
O=C(O)CC[C@@H](C(O)=O)NC([C@@]1(C)N(C(CN)=O)CCC1)=O
Molecular Formula
C13H21N3O6
Molecular Weight
315.32
References & Citations
[1]Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19.|[2]Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29 (12) :1924-32.|[3]Cartagena CM, Phillips KL, Williams GL, et al. Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3. Neuromolecular Med. 2013;15 (3) :504-514.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)
Scientific Category
Peptides
Clinical Information
Launched
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
MBS287887-03 5x 96 Tests
Bovine Toll-like receptor 2 (TLR2) ELISA Kit
Sign In for Pricing
View Details MBS287887-04 10x 96 Tests
Bovine Toll-like receptor 2 (TLR2) ELISA Kit
Sign In for Pricing
View Details 