Prinomastat
Prinomastat (AG3340) is a broad spectrum, potent, orally active metalloproteinase (MMP) inhibitor with IC50s of 79, 6.3 and 5.0 nM for MMP-1, MMP-3 and MMP-9, respectively. Prinomastat inhibits MMP-2, MMP-3, MMP-13 and MMP-9 with Kis of 0.05 nM, 0.3 nM, 0.03 nM and 0.26 nM, respectively. Prinomastat crosses blood-brain barrier. Antitumor avtivity[1][2][3][4].
Product Specifications
CAS Number
192329-42-3
Product Name Alternative
AG3340; KB-R9896
UNSPSC
12352005
Hazard Statement
H360
Target
Apoptosis; MMP
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Prinomastat.html
Purity
99.27
Solubility
1 M HCl : 25 mg/mL (ultrasonic) |DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 2.5 mg/mL (ultrasonic; adjust pH to 3 with HCl)
Smiles
O=C([C@@H]1N(S(=O)(C2=CC=C(OC3=CC=NC=C3)C=C2)=O)CCSC1(C)C)NO
Molecular Formula
C18H21N3O5S2
Molecular Weight
423.51
Precautions
H360
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
MMP-1; MMP-13; MMP-2; MMP-3; MMP-9
Citation 01
KTH Royal Institute of Technology. 2025.|Sci Adv. 2023 Jan 20;9 (3) :eadd3867.|J Neuropathol Exp Neurol. 2022 Sep 19;81 (10) :816-824.
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