DMBA

DMBA has carcinogenic activity as a polycyclic aromatic hydrocarbon (PAH) . DMBA is used to induce tumor formation in various rodent models[1].

Product Specifications

CAS Number

[57-97-6]

Product Name Alternative

7,12-DMBA; 7,12-Dimethylbenzanthracene

UNSPSC

12352005

Hazard Statement

H302, H350

Target

C-Myc

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dmba.html

Purity

99.94

Solubility

Acetone : 25 mg/mL (ultrasonic) |DMSO : 12.5 mg/mL|Ethanol : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC(C1=CC=CC=C21)=C3C=CC4=CC=CC=C4C3=C2C

Molecular Formula

C20H16

Molecular Weight

256.35

Precautions

H302, H350

References & Citations

[1]Csiszar A, Balasubramanian P, Tarantini S, Yabluchanskiy A, Zhang XA, Springo Z, Benbrook D, Sonntag WE, Ungvari Z. Chemically induced carcinogenesis in rodent models of aging: assessing organismal resilience to genotoxic stressors in geroscience research. Geroscience. 2019 Apr;41 (2) :209-227. |[2]HUGGINS C, et al., Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression. Nature. 1961 Jan 21;189:204-7.|[3]Goerttler K, et al., Skin tumor formation in the European hamster (Cricetus cricetus L.) after topical initiation with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion with 12-O-tetradecanoylphorbol-13-acetate (TPA) . Carcinogenesis. 1984 Apr;5 (4) :521-4.|[4]Saini RK, et al., Pulmonary carcinogenesis in mice with a single intratracheal instillation of 9, 10-dimethyl benz[a]anthracene. Drug Chem Toxicol. 2008;31 (4) :459-71.|[5]Gao J, et al., Microsomal expoxide hydrolase is required for 7,12-dimethylbenz[a]anthracene (DMBA) -induced immunotoxicity in mice. Toxicol Sci. 2007 Jul;98 (1) :137-44.