Fumaric acid

Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].

Product Specifications

CAS Number

[110-17-8]

UNSPSC

12352211

Hazard Statement

H319

Target

Endogenous Metabolite; NF-κB; p38 MAPK

Type

Natural Products

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB

Applications

Cancer-programmed cell death

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Fumaric_acid.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic) |H2O : 11.11 mg/mL (ultrasonic)

Smiles

O=C(O)/C=C/C(O)=O

Molecular Formula

C4H4O4

Molecular Weight

116.07

Precautions

H319

References & Citations

[1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8.|[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.