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Nampt-IN-5

Nampt-IN-5 is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-5 also inhibits CYP3A4 activity and has cellular IC50s of 0.7 nM and 3.9 nM against A2780 and COR-L23, respectively[1].

Product Specifications

CAS Number

2380013-17-0

UNSPSC

12352005

Target

Cytochrome P450; NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nampt-in-5.html

Purity

98.02

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1CC(C2=CC=CN=C2)C1)NC3=CC=C(CN4C5=CC=CC=C5N=C4OCC)C=C3

Molecular Formula

C25H25N5O2

Molecular Weight

427.50

References & Citations

[1]Palacios DS, et al. Scaffold Morphing Identifies 3-Pyridyl Azetidine Ureas as Inhibitors of Nicotinamide Phosphoribosyltransferase (NAMPT) .ACS Med Chem Lett. 2019 Oct 10;10 (11) :1524-1529.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CYP3

Available Sizes

Frequently Asked Questions

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