Stafib-2

Stafib-2 is a potent and selctive inhibitor of the transcription factor STAT5b, with an IC50 of 82 nM and 1.7 μM for STAT5b and STAT5a, respectively. Stafib-2 exhibits poor cell permeability[1].

Product Specifications

CAS Number

2097938-74-2

UNSPSC

12352005

Target

STAT

Type

Reference compound

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/stafib-2.html

Purity

99.97

Solubility

DMSO : 48 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(OC2=CC=CC=C2)C=C1)C3=CC=C(OCC(NCC4=CC=C(OP(O)(O)=O)C(OP(O)(O)=O)=C4)=O)C=C3

Molecular Formula

C28H26N2O12P2

Molecular Weight

644.46

References & Citations

[1]Elumalai N, et, al. Rational development of Stafib-2: a selective, nanomolar inhibitor of the transcription factor STAT5b. Sci Rep. 2017 Apr 11;7 (1) :819.