NAMI-A

NAMI-A is a ruthenium-based agent characterized by selective activity against tumor metastasis, inhibiting adhesion and migration.

Product Specifications

CAS Number

[201653-76-1]

UNSPSC

12352005

Target

FAK

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/NAMI-A.html

Concentration

10mM

Purity

98.0

Solubility

H2O : 8.28 mg/mL (ultrasonic; warming)

Smiles

Cl[Ru](Cl)(Cl)(Cl)(C)[N]1=CNC=C1.O=S(C)C.[H+].C2=CNC=N2

Molecular Formula

C5H10Cl4N2ORuS.C3H4N2.H

Molecular Weight

458.18

References & Citations

[1]Sava G et al. Dual Action of NAMI-A in inhibition of solid tumor metastasis: selective targeting of metastatic cells and binding to collagen. Clin Cancer Res. 2003 May;9 (5) :1898-905.|[2]Pelillo C et al. Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A. J Inorg Biochem. 2016 Jul;160:225-35.