MP-A08

MP-A08 is a highly selective ATP competitive sphingosine kinase (SPHK1) inhibitor that targets both SphK1 and SphK2 with Ki values of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively.

Product Specifications

CAS Number

[219832-49-2]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

SphK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/MP-A08.html

Purity

98.0

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=S(C1=CC=C(C)C=C1)(NC2=CC=CC=C2/C=N/C3=CC=CC=C3NS(=O)(C4=CC=C(C)C=C4)=O)=O

Molecular Formula

C27H25N3O4S2

Molecular Weight

519.64

Precautions

H315, H319

References & Citations

[1]Pitman MR et al. A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties. Oncotarget, 2015 Mar 30, 6 (9) :7065-83.|[2]Dimasi DP et al. Examining the Role of Sphingosine Kinase-2 in the Regulation of Endothelial Cell Barrier Integrity. Microcirculation, 2016 Apr, 23 (3) :248-65.