5-PA-dUTP

5-PA-dUTP (5-Propargylamino-dUTP) is a C5-modified nucleotide and can be incorporated into DNA nanoparticles (DNPs) for photosensitizer delivery[1]. 5-PA-dUTP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Product Specifications

CAS Number

[179101-49-6]

Product Name Alternative

5-Propargylamino-dUTP

UNSPSC

12352200

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis

Type

Biochemical Assay Reagents

Related Pathways

Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/5-pa-dutp.html

Concentration

100 mM * 100 μL in Triethylamine

Purity

99.59

Solubility

H2O : 125 mg/mL (ultrasonic)

Smiles

O=C1N([C@H]2C[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O2)C=C(C(N1)=O)C#CCN

Molecular Formula

C12H18N3O14P3

Molecular Weight

521.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Kyoung-Ran Kim, et al.Shaping Rolling Circle Amplification Products into DNA Nanoparticles by Incorporation of Modified Nucleotides and Their Application to In Vitro and In Vivo Delivery of a Photosensitizer. Molecules. 2018 Jul 23;23 (7) :1833.