GNF-8625
GNF-8625 is a broad-spectrum TRK inhibitor that can combine with Thalidomide to form a PROTAC degrader. The IC50 of GNF-8625 for inhibiting TRKA, TRKB, and TRKC are 0.8 nM, 22 nM, and 5.4 nM, respectively.
Product Specifications
CAS Number
1196546-33-4
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; Trk Receptor
Type
Reference compound
Related Pathways
Neuronal Signaling; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gnf-8625.html
Smiles
FC1=CC=CC([C@@H]2N(CCC2)C3=NN4C(C5=CC=CC(C6=CC=NC(N7CCC(CC7)O)=C6)=N5)=CN=C4C=C3)=C1
Molecular Formula
C31H30FN7O
Molecular Weight
535.61
References & Citations
[1]Selectively targeting tropomyosin receptor kinase a (TRKA) via PROTACs
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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