PDZ1 Domain inhibitor peptide (TFA)
Product Specifications
UNSPSC Description
PDZ1 Domain inhibitor peptide TFA, a cyclic peptide, incorporates a β-Ala lactam side chain linker and targets the PDZ1 domains of the postsynaptic density protein 95 (PSD-95). PDZ1 Domain inhibitor peptide TFA disrupts the GluR6/PSD-95 interaction and is very efficient in competing against the C terminus of GluR6 for the PDZ1 domain[1].
Target Antigen
iGluR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pdz1-domain-inhibitor-peptide-tfa.html
Solubility
H2O
Smiles
O=C([C@H](CCCCN)NC([C@@H](N)CC1=CC=C(O)C=C1)=O)N[C@@H]2C(N[C@@](C(N[C@@H](CCC(NCCCC2)=O)C(N[C@@H](C)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)([H])[C@H](O)C)=O.OC(C(F)(F)F)=O
Molecular Weight
933.97
References & Citations
[1]Andrea Piserchio, et al. Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. Chem Biol. 2004 Apr;11(4):469-73.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1195A/PDZ1-Domain-inhibitor-peptide-TFA-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1195A/
Clinical Information
No Development Reported
Curated Selection
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