5-HT2A receptor agonist-3
5-HT2A receptor agonist-3 is the most selective agonist for the human 5-HT2A receptor yet discovered, with a Ki of 2.5 nM, and with 124-fold selectivity for 5-HT2A over the structurally similar 5-HT2C receptor[1].
Product Specifications
CAS Number
[1391499-52-7]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/5-ht2a-receptor-agonist-3.html
Purity
98.53
Solubility
10 mM in DMSO
Smiles
COC1=C([C@H]2N[C@@H](CCC2)CC3=C(C=C(C(OC)=C3)Br)OC)C=CC=C1
Molecular Formula
C21H26BrNO3
Molecular Weight
420.34
References & Citations
[1]Juncosa JI Jr, et al. Extensive rigid analogue design maps the binding conformation of potent N-benzylphenethylamine 5-HT2A serotonin receptor agonist ligands. ACS Chem Neurosci. 2013;4 (1) :96-109.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT2 Receptor
Available Sizes
Curated Selection
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