Alpha-1,3-Galactosyltransferase (a1,3GalT)

Alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species[1].

Product Specifications

CAS Number

[128449-51-4]

Product Name Alternative

GGTA1

UNSPSC

12352204

Target

Endogenous Metabolite

Type

Enzyme

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/alpha-1-3-galactosyltransferase-a1-3galt.html

Solubility

10 mM in DMSO

Smiles

[alpha-1,3-Galactosyltransferase(a1,3GalT)]

References & Citations

[1]Sumnima Singh, et al. Loss of α-gal during primate evolution enhanced antibody-effector function and resistance to bacterial sepsis. Cell Host Microbe. 2021 Mar 10;29 (3) :347-361.e12.|[2]Anne-Laure Turcot-Dubois, et al. Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals--a birth-and-death evolution model. Glycobiology. 2007 May;17 (5) :516-28.