YM511
Product Specifications
UNSPSC Description
YM511 is a highly specific non-steroidal aromatase inhibitor. YM511 inhibits aromatase activities in microsomes from rat ovary and human placenta competitively (IC50s of 0.4 and 0.12 nM, respectively). YM511 slightly inhibits production of other steroid hormones. YM511 has the potential for suppressing estrogen-dependent action research without affecting serum levels of other steroid hormones[1].
Target Antigen
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/ym511.html
Purity
99.73
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
BrC(C=C1)=CC=C1CN(N2C=NN=C2)C3=CC=C(C#N)C=C3
Molecular Weight
354.20
References & Citations
[1]M Kudoh, et al. The potent and selective inhibition of estrogen production by non-steroidal aromatase inhibitor, YM511. J Steroid Biochem Mol Biol. 1995 Sep;54(5-6):265-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-105184/YM511-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-105184/YM511-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
148869-05-0
Available Sizes
Curated Selection
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