MMAE-SMCC

MMAE-SMCC is a agent-linker conjugate for ADC. MMAE-SMCC is composed of a potent mitotic and a tubulin inhibitor MMAE and a linker SMCC to make antibody agent conjugate.

Product Specifications

CAS Number

[2021179-11-1]

UNSPSC

12352203

Target

Drug-Linker Conjugates for ADC

Type

ADC Related

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mmae-smcc.html

Purity

99.56

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCSC(C3)C(N(CC4CCC(C(ON5C(CCC5=O)=O)=O)CC4)C3=O)=O)=O)=O)=O)=O)OC)=O

Molecular Formula

C58H89N7O14S

Molecular Weight

1140.43

References & Citations

[1]Tang F, et al. One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody-drug conjugates. Org Biomol Chem. 2016 Oct 12;14 (40) :9501-9518.