Cinromide
Cinromide is an anticonvulsant agent. Cinromide inhibits epithelial neutral amino acid transporter B0AT1 (SLC6A19) with an IC50 of 0.5 μM[1][2].
Product Specifications
CAS Number
58473-74-8
Product Name Alternative
Trans-3-Bromo-N-ethylcinnamamide
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amino acid Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Cinromide.html
Purity
99.83
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NCC)/C=C/C1=CC=CC(Br)=C1
Molecular Formula
C11H12BrNO
Molecular Weight
254.12
Precautions
H302, H315, H319, H335
References & Citations
[1]Chiu P, et al. The effect of cinromide on "kindled" seizures in the rat. Neuropharmacology. 1982;21 (3) :273-276.|[2]Yadav A, et al. Novel Chemical Scaffolds to Inhibit the Neutral Amino Acid Transporter B0AT1 (SLC6A19), a Potential Target to Treat Metabolic Diseases. Front Pharmacol. 2020;11:140. Published 2020 Feb 28.|[3]Soroko FE, et al. Cinromide (3-bromo-N-ethylcinnanamide), novel anticonvulsant agent. J Pharm Pharmacol. 1981 Nov;33 (11) :741-3.|[4]Fromm GH, et al. Effect of cinromide on inhibitory and excitatory mechanisms. Epilepsia. 1983 Aug;24 (4) :394-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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