BU224 (hydrochloride)
BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].
Product Specifications
CAS Number
205437-64-5
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Apoptosis; Imidazoline Receptor; TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bu224-hydrochloride.html
Purity
96.96
Solubility
DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1(C2=NCCN2)=NC3=CC=CC=C3C=C1.Cl
Molecular Formula
C12H12ClN3
Molecular Weight
233.70
Precautions
H302, H315, H319
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNFRSF5/CD40
Available Sizes
Frequently Asked Questions
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