BU224 (hydrochloride)

BU224 hydrochloride is a selective and high affinity imidazoline I2 receptor ligand, with a Ki of 2.1 nM. BU224 hydrochloride is sometimes used as an I2 receptor antagonist. BU224 hydrochloride exerts neuroprotective effects, with anti-inflammatory and anti-apoptotic properties. BU224 hydrochloride improves memory in 5XFAD mice, enlarging dendritic spines and reducing Aβ-induced changes in NMDARs. BU224 hydrochloride can be used for Alzheimer's disease research[1][2][3].

Product Specifications

CAS Number

[205437-64-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Apoptosis; Imidazoline Receptor; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/bu224-hydrochloride.html

Purity

96.96

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1(C2=NCCN2)=NC3=CC=CC=C3C=C1.Cl

Molecular Formula

C12H12ClN3

Molecular Weight

233.70

Precautions

H302, H315, H319

References & Citations

[1]Mirzaei N, et al. Imidazoline ligand BU224 reverses cognitive deficits, reduces microgliosis and enhances synaptic connectivity in a mouse model of Alzheimer's disease. Br J Pharmacol. 2021 Feb;178 (3) :654-671. |[2]Finn DP, et al. Behavioral, neuroendocrine and neurochemical effects of the imidazoline I2 receptor selective ligand BU224 in naive rats and rats exposed to the stress of the forced swim test. Psychopharmacology (Berl) . 2003 May;167 (2) :195-202. |[3]Qiu Y, et al. Discriminative stimulus effects of the imidazoline I2 receptor ligands BU224 and phenyzoline in rats. Eur J Pharmacol. 2015 Feb 15;749:133-41.