CW2158
Product Specifications
UNSPSC Description
CW2158 (Compound 13) is a modulator for exportin1 (XPO1) ,which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].
Target Antigen
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cw2158.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C(N=C1NN2C(C=C(C)C2=O)=O)=NC3=C1C(F)=CC=C3
Molecular Weight
340.23
References & Citations
[1]Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-161392/CW2158-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-161392/
Clinical Information
No Development Reported
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
