CW2158
CW2158 (Compound 13) is a modulator for exportin1 (XPO1), which disrupts the chromatin binding, inhibits NFAT transcription factors and activation of T cells[1].
Product Specifications
UNSPSC
12352005
Target
CRM1
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cw2158.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C(N=C1NN2C(C=C(C)C2=O)=O)=NC3=C1C(F)=CC=C3
Molecular Formula
C14H8F4N4O2
Molecular Weight
340.23
References & Citations
[1]Chen YF, et al., Targeting the chromatin binding of exportin-1 disrupts NFAT and T cell activation. Nat Chem Biol. 2024 Mar 25.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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