DNA-RNA Hybrid Monoclonal Antibody[S9.6]
Product Specifications
Background
The DNA-RNA hybrids are a natural occurrence within eukaryotic cells and their level are high at sites of high transcriptional activity. They are non-canonical nucleic acid structures with transcriptional regulatory functions. Their presence is reported to predispose a locus to chromosomal breakage. The S9.6 monoclonal antibody recognizes DNA-RNA hybrids (also known as R-loops) and does not bind to single or double stranded DNA. The antibody has high affinity for DNA?RNA hybrids but also binds RNA-RNA hybrids that are AU-rich. The specificity of the antibody appears to be determined by a combination of sequence and structural dependency since R?loop sequence affects binding affinity.
Abbreviation
DNA-RNA Hybrid
Host
Mouse
Reactivity
All
Immunogen
ΦX174 bacteriophage-derived synthetic DNA/RNA
Target
DNA-RNA hybrid; RNA/DNA hybrid
Clone
S9.6
Conjugation
Unconjugated
Applications
IF; ChIP
Purification
Protein A/G Purification
Concentration
1 mg/mL
Dilution
IF 1:200; ChIP 1:50-500
Buffer
PBS with 0.02% sodium azide,1% protective protein and 50% glycerol, pH7.4
Shipping Conditions
The product is shipped with ice pack, upon receipt, store it immediately at the temperature recommended.
Storage Conditions
Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Product Datasheet
https://789.bio/ea/4duyel
Isotype
IgG2a
Available Sizes
Curated Selection
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