Ac-Nle-Pro-Nle-Asp-AMC
Ac-Nle-Pro-Nle-Asp-AMC is a specific substrate for 26S proteasome. Ac-Nle-Pro-Nle-Asp-AMC can be used for the 26S proteasome caspase-like activity analysis[1][2][3].
Product Specifications
CAS Number
355140-49-7
UNSPSC
12352209
Target
Proteasome
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-nle-pro-nle-asp-amc.html
Purity
98.72
Solubility
DMSO : ≥ 100 mg/mL
Smiles
CCCC[C@H](NC([C@@H]1CCCN1C([C@@H](NC(C)=O)CCCC)=O)=O)C(N[C@H](C(NC2=CC3=C(C(C)=CC(O3)=O)C=C2)=O)CC(O)=O)=O
Molecular Formula
C33H45N5O9
Molecular Weight
655.74
References & Citations
[1]Dunlop RA, et al. The impact of specific oxidized amino acids on protein turnover in J774 cells. Biochem J. 2008 Feb 15;410 (1) :131-40.|[2]Kirk-Ballard H, et al. An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes. PLoS One. 2013;8 (2) :e57112.|[3]Pakavathkumar P, et al. Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine. Sci Rep. 2015 Sep 24;5:13730.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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