18:1 PEG5000 PE (ammonium)

18:1 PEG5000 PE ammonium (DOPE-PEG5000 ammonium) is a PEG lipid functional end group used in the synthesis of liposomes (LPs) for the design of conjugated polymer nanoparticles. Through biotin modification and carboxyl terminus, lipid nanoparticles (LNPs) further coupling with other biomolecules can be achieved. Functionalized nanoparticles can be used for targeted labeling of specific cellular proteins. With streptavidin as a linker, biotinylated PEG lipid-conjugated polymer nanoparticles are able to bind to biotinylated antibodies on cell surface receptors, yielding the utility of fluorescence-based imaging and sensing.

Product Specifications

CAS Number

[474922-90-2]

Product Name Alternative

DOPE-PEG5000 (ammonium) ; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol) -5000] (ammonium)

UNSPSC

12352200

Hazard Statement

H302-H315-H319-H331-H336-H351-H361-H372

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/18-1-peg5000-pe.html

Solubility

10 mM in DMSO

Smiles

O=C(OCCOC)NCCOP(O)(OC[C@H](OC(CCCCCCC/C=C\CCCCCCCC)=O)COC(CCCCCCC/C=C\CCCCCCCC)=O)=O.[n].N

Molecular Formula

(C2H4O) nC43H80NO10P.NH3

Molecular Weight

5000 (Average)

Precautions

P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Andresen TL, et al. Compositional inhomogeneity of drug delivery liposomes quantified at the single liposome level. Acta Biomater. 2020 Dec;118:207-214.