ML 10302 (hydrochloride)

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].

Product Specifications

CAS Number

[186826-17-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ml-10302-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl

Molecular Formula

C15H22Cl2N2O3

Molecular Weight

349.25

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4 (12), 1433–1436.|[2]D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40 (4) :608-21.|[3]M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150 (7) : 883–892.