ML 10302 (hydrochloride)
Product Specifications
UNSPSC Description
ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay[1][2].
Target Antigen
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ml-10302-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(OCCN1CCCCC1)C2=CC(Cl)=C(N)C=C2OC.[H]Cl
Molecular Weight
349.25
References & Citations
[1]Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.|[2]D Yang, et al. New esters of 4-amino-5-chloro-2-methoxybenzoic acid as potent agonists and antagonists for 5-HT4 receptors. J Med Chem. 1997 Feb 14;40(4):608-21.|[3]M Cachard-Chastel, et al. 5-HT4 receptor agonists increase sAPPα levels in the cortex and hippocampus of male C57BL/6j mice. Br J Pharmacol. 2007 Apr; 150(7): 883–892.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14442/ML-10302-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14442/
Clinical Information
No Development Reported
CAS Number
186826-17-5
Available Sizes
Curated Selection
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