Timosaponin A1

Timosaponin A1, a natural steroidal saponin, is a 5-lipoxygenase (5-LO), COX-2, and dipeptidyl peptidase 4 (DPP-4) inhibitor with IC50s of 3.29 µM, 36.43 µM, and 33.25 µM, respectively[1][2].

Product Specifications

CAS Number

[68422-00-4]

UNSPSC

12352005

Target

COX; Dipeptidyl Peptidase; Lipoxygenase

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Timosaponin_A1.html

Purity

99.70

Solubility

DMSO : 31.25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[C@@]12[C@]3([H])[C@](O[C@]4(CC[C@H](C)CO4)[C@H]3C)([H])C[C@@]1([H])[C@@]5([H])[C@]([C@@]6([C@](C[C@@H](O[C@]7([H])O[C@@H]([C@H](O)[C@H](O)[C@H]7O)CO)CC6)([H])CC5)C)([H])CC2

Molecular Formula

C33H54O8

Molecular Weight

578.78

References & Citations

[1]Shumin Jiang, et al. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. Eur J Pharmacol. 2020 Sep 5:882:173272. |[2]Linlin Xie, et al. Characterization of spirostanol glycosides and furostanol glycosides from anemarrhenae rhizoma as dual targeted inhibitors of 5-lipoxygenase and Cyclooxygenase-2 by employing a combination of affinity ultrafiltration and HPLC/MS. Phytomedicine. 2020 Oct:77:153284.