ZK824859 (hydrochloride)
Product Specifications
Product Name Alternative
TC-1734; ACD3480
UNSPSC Description
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively[1].
Target Antigen
PAI-1; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zk824859-hydrochloride.html
Purity
99.03
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CC1=CC(OC2=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N2)=CC(C3=CC=CC(CN)=C3)=C1.Cl
Molecular Weight
464.89
References & Citations
[1]Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-114330A/ZK824859-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-114330A/ZK824859-hydrochloride-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2436760-76-6
Available Sizes
Curated Selection
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