ZK824859 (hydrochloride)
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively[1].
Product Specifications
CAS Number
[2436760-76-6]
Product Name Alternative
TC-1734; ACD3480
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
PAI-1; Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/zk824859-hydrochloride.html
Purity
99.03
Solubility
DMSO : ≥ 125 mg/mL
Smiles
CC1=CC(OC2=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N2)=CC(C3=CC=CC(CN)=C3)=C1.Cl
Molecular Formula
C23H23ClF2N2O4
Molecular Weight
464.89
Precautions
H302, H312, H332
References & Citations
[1]Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3372-3375.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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