ZK824859 (hydrochloride)

ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC50s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively[1].

Product Specifications

CAS Number

[2436760-76-6]

Product Name Alternative

TC-1734; ACD3480

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

PAI-1; Ser/Thr Protease

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/zk824859-hydrochloride.html

Purity

99.03

Solubility

DMSO : ≥ 125 mg/mL

Smiles

CC1=CC(OC2=C(F)C=C(F)C(O[C@H](CC)C(O)=O)=N2)=CC(C3=CC=CC(CN)=C3)=C1.Cl

Molecular Formula

C23H23ClF2N2O4

Molecular Weight

464.89

Precautions

H302, H312, H332

References & Citations

[1]Islam I, et al. Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28 (20) :3372-3375.