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Bisandrographolide C

Product Specifications

UNSPSC Description

Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury[1].

Target Antigen

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel;Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/bisandrographolide-c.html

Solubility

10 mM in DMSO

Smiles

C[C@]([C@]1([H])CCC2=C)(CC[C@@H](O)[C@@]1(C)CO)[C@@H]2/C=C/C3=C[C@H](OC3=O)[C@H](C4=CCOC4=O)C[C@H]5[C@@](CC[C@@H](O)[C@@]6(C)CO)(C)[C@]6([H])CCC5=C

Molecular Weight

664.87

References & Citations

[1]Gao S, et al. Unusual ent-Labdane Diterpenoid Dimers and their Selective Activation of TRPV Channels. J Org Chem. 2019 Nov 1;84(21):13595-13603.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-N2941/Bisandrographolide-C-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-N2941/

Clinical Information

No Development Reported

CAS Number

160498-02-2

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