Gemcitabine monophosphate

Gemcitabine monophosphate (Gemcitabine 5′-phosphate) is one of the active intermediates of Gemcitabine (HY-17026) . Gemcitabine monophosphate has a synergistic anti-cancer effect and can be delivered by formulating it into nanoparticles[1][2].

Product Specifications

CAS Number

[116371-67-6]

Product Name Alternative

Gemcitabine 5′-phosphate

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gemcitabine-monophosphate.html

Purity

99.98

Solubility

DMSO : 200 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

OP(OC[C@@H]1[C@@H](O)C(F)(F)[C@H](N2C=CC(N)=NC2=O)O1)(O)=O

Molecular Formula

C9H12F2N3O7P

Molecular Weight

343.18

Precautions

H315, H319, H335

References & Citations

[1]Zhang Y, et al. Codelivery of VEGF siRNA and gemcitabine monophosphate in a single nanoparticle formulation for effective treatment of NSCLC. Mol Ther. 2013 Aug;21 (8) :1559-69. |[2]Miao L, et al. Nanoparticles with Precise Ratiometric Co-Loading and Co-Delivery of Gemcitabine Monophosphate and Cisplatin for Treatment of Bladder Cancer. Adv Funct Mater. 2014 Nov 12;24 (42) :6601-6611.