FR194738 free base

FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC50 of 9.8 nM.

Product Specifications

CAS Number

[204067-45-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/FR194738_free_base.html

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(OCC1=CSC=C1)(C)COC2=CC(CN(C/C=C/C#CC(C)(C)C)CC)=CC=C2

Molecular Formula

C27H37NO2S

Molecular Weight

439.65

Precautions

H302, H315, H319, H335

References & Citations

[1]Sawada M, et al. Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells. Eur J Pharmacol. 2001 Nov 9;431 (1) :11-6.|[2]Sawada M, et al. Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14 (3) :633-7.|[3]Sawada M, et al. Inhibition of cholesterol synthesis causes both hypercholesterolemia and hypocholesterolemia in hamsters. Biol Pharm Bull. 2002 Dec;25 (12) :1577-82.