Amelparib
Product Specifications
UNSPSC Description
Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC50=18.5 nM) and cellular PAR formation (IC50=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke[1].
Target Antigen
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/amelparib.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic;adjust pH to 2 with 1M HCl)
Smiles
O=C1C2=C(C3=C(C=C(C=C3N1)CN4CCOCC4)OCC)NCCC2
Molecular Weight
343.42
References & Citations
[1]Kim Y, et al. Neuroprotective effects of a novel poly (ADP-ribose) polymerase-1 inhibitor, JPI-289, in hypoxic rat cortical neurons. Clin Exp Pharmacol Physiol. 2017;44(6):671-679.|[2]Youngchul Kim, et al. Early treatment with poly (ADP-ribose) polymerase-1 inhibitor (JPI-289) reduces infarct volume and improves long-term behavior in an animal model of ischemic stroke. Molecular neurobiology 55 (2018): 7153-7163.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-116218/Amelparib-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-116218/Amelparib-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
1227156-72-0
Available Sizes
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