Amelparib
Amelparib (JPI-289 free base) is a potent, orally active, and water-soluble inhibitor of PARP-1. Amelparib inhibits PARP-1 activity (IC50=18.5 nM) and cellular PAR formation (IC50=10.7 nM) in the nanomolar range. Amelparib is a potential neuroprotective agent. Amelparib has the potential for the research of acute ischaemic stroke[1].
Product Specifications
CAS Number
1227156-72-0
Product Name Alternative
JPI-289 (free base)
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/amelparib.html
Purity
99.17
Solubility
DMSO : 100 mg/mL (ultrasonic; adjust pH to 2 with 1M HCl)
Smiles
O=C1C2=C(C3=C(C=C(C=C3N1)CN4CCOCC4)OCC)NCCC2
Molecular Formula
C19H25N3O3
Molecular Weight
343.42
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
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