PARP1/BRD4-IN-3
PARP1/BRD4-IN-3 (compound HF4) is a potent BRD4 and PARP1 inhibitor with IC50 values of 1210, 2019 nM for BRD4, PARP1, respectively. PARP1/BRD4-IN-3 shows antiproliferative activities. PARP1/BRD4-IN-3 induces apoptosis and cell cycle arrest at G0/G1 phase. PARP1/BRD4-IN-3 causes DNA damage and reduces the protein expression of Rad51. PARP1/BRD4-IN-3 shows antitumor efficacy[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Epigenetic Reader Domain; PARP
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-brd4-in-3.html
Smiles
O=S(C1=CC=C(F)C(C)=C1)(NC2=CC3=C(NC(C(CC)=C3)=O)C=C2)=O
Molecular Formula
C18H17FN2O3S
Molecular Weight
360.40
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD2; BRD3; BRD4; PARP1
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