QS-57

QS-57 is a PROTAC targeting BRD4. QS-57 can be used as a 14-3-3 molecular glue. (Red: EN171 (HY-W1005067), black: (2-Aminoethyl) carbamic acid (HY-W398806), Blue: JQ-1 (carboxylic acid) (HY-78695) ) [1].

Product Specifications

UNSPSC

12352005

Target

Molecular Glues; PROTACs

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/qs-57.html

Smiles

C=CC(N1CCC2(C1)CCN(C2)CC3=CC=C(C=C3)C(NCCNC(C[C@@H]4N=C(C5=C(N6C(C)=NN=C46)SC(C)=C5C)C7=CC=C(C=C7)Cl)=O)=O)=O

Molecular Formula

C39H43ClN8O3S

Molecular Weight

739.33

References & Citations

[1]Shao Q, et al. Targeted Protein Localization by Covalent 14–3–3 Recruitment[J]. Journal of the American Chemical Society, 2024.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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