TMX-4153
TMX-4153 is a selective PIP4K2C PROTAC degrader. TMX-4153 induces PIP4K2C degradation in MOLT4 cells (DC50 = 24 nM) and HAP1 cells (DC50 = 361 nM). TMX-4153 can be used for the study of biological functions of PIP4K2C (immune modulation) -related diseases. (Pink: BTK ligand , Blue: VHL Ligand (HY-112078), Black: Linker).
Product Specifications
CAS Number
2867519-91-1
UNSPSC
12352005
Target
PIKfyve; PROTACs
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; PROTAC
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tmx-4153.html
Purity
98.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=CN=C(N=C1C2=CC=CC(C3=CC=CC=C3)=C2)NC4=CC(N(C5=O)CCC5(CC6)CCN6C(CCCCCC(N[C@H](C(N7[C@H](C(N[C@@H](C)C8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O)C(C)(C)C)=O)=O)=CN=C4
Molecular Formula
C59H67ClN10O6S
Molecular Weight
1079.74
References & Citations
[1]Teng M, et al. Targeting the Dark Lipid Kinase PIP4K2C with a Potent and Selective Binder and Degrader. Angew Chem Int Ed Engl. 2023 Apr 24;62 (18) :e202302364.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)
Available Sizes
Frequently Asked Questions
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