dAURK-4 (hydrochloride)
Product Specifications
UNSPSC Description
dAURK-4 hydrochloride, an Alisertib (HY-10971) derivative, is a potent and selective PROTAC AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects. (Pink: Ligand for target protein (HY-10971); Black: Linker (HY-W004640); Blue: Ligand for E3 ligase Thalidomide-O-COOH (HY-103597))[1].
Target Antigen
Aurora Kinase; PROTACs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics;PROTAC
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/daurk-4-hydrochloride.html
Smiles
O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O.Cl
Molecular Weight
1071.93
References & Citations
[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183(6):1714-1731.e10.
Shipping Conditions
Blue Ice
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137344A/dAURK-4-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137344A/dAURK-4-hydrochloride-SDS-MedChemExpress.pdf
Available Sizes
Curated Selection
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