DAURK-4 (hydrochloride)

DAURK-4 hydrochloride, an Alisertib (HY-10971) derivative, is a potent and selective PROTAC AURKA (Aurora A) degrader. dAURK-4 hydrochloride has anticancer effects. (Pink: Ligand for target protein (HY-10971) ; Black: Linker (HY-W004640) ; Blue: Ligand for E3 ligase Thalidomide-O-COOH (HY-103597) ) [1].

Product Specifications

UNSPSC

12352005

Target

Aurora Kinase; PROTACs

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/daurk-4-hydrochloride.html

Purity

99.44

Solubility

DMSO : 66.67 mg/mL (ultrasonic)

Smiles

O=C(N(C1C(NC(CC1)=O)=O)C2=O)C3=C2C=CC=C3OCC(NCCCOCCOCCOCCCNC(C4=CC=C(NC5=NC=C6C(C(C=CC(Cl)=C7)=C7C(C8=C(F)C=CC=C8OC)=NC6)=N5)C=C4OC)=O)=O.Cl

Molecular Formula

C52H53Cl2FN8O12

Molecular Weight

1071.93

References & Citations

[1]Katherine A Donovan, et al. Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development. Cell. 2020 Dec 10;183 (6) :1714-1731.e10.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Aurora A

Available Sizes

Curated Selection

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