BMS-250749

BMS-250749 is a topoisomerase I (Top I) inhibitor of the fluoroglycosyl-3,9-difluoroindolecarbazole class. BMS-250749 exhibits potent cytotoxicity and selectivity, and shows curative antitumor activity against Lewis lung cancer. BMS-250749 exhibits broad-spectrum antitumor activity superior to CPT-11 in certain preclinical xenograft models.[1].

Product Specifications

CAS Number

[406913-72-2]

UNSPSC

12352005

Target

Topoisomerase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-250749.html

Smiles

O=C1NC(C2=C1C3=C(NC4=C3C=C(C=C4)F)C5=C2C6=C(C=CC(F)=C6)N5[C@H]7[C@H](O)[C@@H](O)[C@@H]([C@H](O7)CO)F)=O

Molecular Formula

C26H18F3N3O6

Molecular Weight

525.43

References & Citations

[1]Discovery of a Fluoroindolo[2,3-a]carbazole Clinical Candidate with Broad Spectrum Antitumor Activity in Preclinical Tumor Models Superior to the Marketed Oncology Drug, CPT-11