FK888
FK888 is a potent, selective, and high affinity dipeptide NK1 receptor antagonist. FK888 displaces [3H]-SP binding with a Ki value of 0.69 nM and 0.45 microM. FK888 also inhibits SP-induced airway oedema in guinea-pig after both intravenous and oral administration[1].
Product Specifications
CAS Number
138449-07-7
UNSPSC
12352005
Target
Neurokinin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/fk888.html
Solubility
10 mM in DMSO
Smiles
O=C(N(C[C@@H]1O)[C@@H](C1)C(N[C@H](C(N(C)CC2=CC=CC=C2)=O)CC3=CC(C=CC=C4)=C4C=C3)=O)C(C5=CC=CC=C56)=CN6C
Molecular Formula
C36H36N4O4
Molecular Weight
588.70
References & Citations
[1]Fujii T, et al. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Br J Pharmacol. 1992;107 (3) :785-789.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
NK1R
Available Sizes
Frequently Asked Questions
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