Erastin2
Erastin2, an Erastin analog, is a ferroptosis inducer and a potent, selective inhibitor of the system xc (-) cystine/glutamate transporter[1][2][3][4]
Product Specifications
CAS Number
1695533-44-8
UNSPSC
12352005
Target
Ferroptosis
Type
Reference compound
Related Pathways
Apoptosis
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/erastin2.html
Concentration
10mM
Purity
98.55
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(N=C(CN3CCN(CC3)C(COC4=CC=C(C=C4)Cl)=O)N1C5=C(OC(C)C)C=CC(C6=CC=CC=C6)=C5)C=CC=C2
Molecular Formula
C36H35ClN4O4
Molecular Weight
623.14
References & Citations
[1]Cao JY, et al. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019 Feb 5;26 (6) :1544-1556.e8. |[2]Dixon SJ, et al. Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife. 2014 May 20;3:e02523. |[3]Conlon M, et al. A compendium of kinetic modulatory profiles identifies ferroptosis regulators[J]. Nat Chem Biol. 2021 Jun;17 (6) :665-674.|[4]Tarangelo A, et al. p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Rep. 2018 Jan 16;22 (3) :569-575.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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