PROTAC SMARCA2 degrader-22
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 [1].
Product Specifications
CAS Number
2760246-90-8
UNSPSC
12352005
Target
PROTACs; SWI/SNF Complex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-22.html
Smiles
OC(C=CC=C1)=C1C2=CC(C(C=N3)=CC=C3N(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=CN=N2
Molecular Formula
C44H51N9O5S
Molecular Weight
818.00
References & Citations
[1]ABBINENI C, et al., 6-substituted pyridazine compounds as smarca2 and/or smarca4 degraders. WO2022029617 A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
ZNF680 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
Recombinant Mouse Heat shock cognate 71 kDa protein (Hspa8)