PROTAC SMARCA2 degrader-22
PROTAC SMARCA2 degrader-22 (Compound 5) is a PROTAC degrader for SMARCA2 with a degradation efficacy of 94% at 100 nM. PROTAC SMARCA2 degrader-22 inhibits the proliferation of cell A549 with an EC50 [1].
Product Specifications
CAS Number
2760246-90-8
UNSPSC
12352005
Target
PROTACs; SWI/SNF Complex
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-smarca2-degrader-22.html
Smiles
OC(C=CC=C1)=C1C2=CC(C(C=N3)=CC=C3N(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(C)N=CS7)C=C6)C)=O)=O)=O)=CN=N2
Molecular Formula
C44H51N9O5S
Molecular Weight
818.00
References & Citations
[1]ABBINENI C, et al., 6-substituted pyridazine compounds as smarca2 and/or smarca4 degraders. WO2022029617 A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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